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Journal: Frontiers in Pain Research
Article Title: Metabolic resilience governs sex-specific pain recovery during hormonal aging: a multi-omics study of neuropathy in mice
doi: 10.3389/fpain.2025.1655712
Figure Lengend Snippet: Adiponectin and peroxisome proliferator-activated receptor gamma (pPARγ) variation after nerve lesion in AT. (A) Adiponectin measured by enzyme-linked immunosorbent assay (ELISA) in AT at baseline condition (BL) and 7 days after CCI (D7) in male and female mice. Unpaired t -test: BL M vs. D7 M t 4 = 3,879, p = 0.0179 (*); BL F vs. D7 F t 4 = 5,573, p = 0.0051 (*); BL M vs. BL F t 4 = 3,037, p = 0.0385 (°); D7 M vs. D7 F t 4 = −6,219, p = 0.0034 (°°); n = 3 group. (B) pPARγ measured by ELISA in AT at baseline condition (BL) and 7 days after CCI (D7) in male and female mice. Unpaired t -test: BL M vs. D7 M t 4 = 22,629, p < 0.0001 (***); BL F vs. D7 F t 4 = 15.071, p = 0.0001 (**); BL M vs. BL F t 4 = −5,452, p = 0.0055 (°); D7 M vs. D7 F t 4 = −96,779, p < 0.0001 (°°°); n = 3 group.
Article Snippet: Leptin levels in serum and AT were quantified using the
Techniques: Enzyme-linked Immunosorbent Assay